منابع مشابه
Targeting folded RNA: a branched peptide boronic acid that binds to a large surface area of HIV-1 RRE RNA.
On-bead high-throughput screening of a medium-sized (1000-2000 Da) branched peptide boronic acid (BPBA) library consisting of 46,656 unique sequences against HIV-1 RRE RNA generated peptides with binding affinities in the low micromolar range. In particular, BPBA1 had a K(d) of 1.4 μM with RRE IIB, preference for RNA over DNA (27 fold), and selectivity of up to >75 fold against a panel of RRE I...
متن کاملAntitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors
The proteasome degrades numerous regulatory proteins that are critical for tumor growth. Thus, proteasome inhibitors are promising antitumor agents. New proteasome inhibitors, such as tyropeptins and tyropeptin-boronic acid derivatives, have a potent inhibitory activity. Here we report the antitumor effects of two new tyropeptin-boronic acid derivatives, AS-06 and AS-29. AS-06 and AS-29 signifi...
متن کاملBoronic acid and boronic ester containing polyoxometalates.
Three organoboron functionalized polyoxometalates have been synthesized using Schiff base chemistry including a boronic acid, its methyl ester and its trimethylene glycol ester. The compounds have been characterized in the solid state by single crystal diffraction (XRD), FT-IR and elemental analysis and in solution using 1H NMR spectroscopy.
متن کامل(2,4,6-Trimethylphenyl)boronic acid–triphenylphosphine oxide (1/1)
In the crystal structure of the title compound, C(9)H(13)BO(2)·C(18)H(15)OP, there are O-H⋯O hydrogen bonds between the O atom of triphenyl-phosphine oxide and one hy-droxy group of the boronic acid. Boronic acid mol-ecules form inversion-related hydrogen-bonded dimers in an R(2) (2)(8) motif. The structure is consolidated by inter-molecular C-H⋯O bonds and C-H⋯π inter-actions.
متن کامل(2,4-Dipropoxyphenyl)boronic acid
In the crystal, the title compound, C(12)H(19)BO(4), exists as a centrosymmetric O-H⋯O hydrogen-bonded dimer. Dimers are linked via C-H⋯O hydrogen bonds, generating an infinite zigzag chain oriented parallel to [1[Formula: see text]1]. The chains are assembled, giving sheets aligned parallel to (21[Formula: see text]) and inter-connected by weak C-H⋯π inter-actions, producing a three-dimensiona...
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ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 1996
ISSN: 2040-2066,2040-2066
DOI: 10.1177/095632029600700208